林华

发布者:林章     发布时间:2020-07-14     动态浏览次数:854

林华 博士


闽江学者”特聘教授

email: hlin@fjnu.edu.cn


教育及科研经历

1998.9-2002.6 复旦大学,化学系,本科

2002.7-2005.8 复旦勤益化学有限公司,研发人员

2005.9-2008.6 复旦大学化学系,硕士

2008.9-2012.6 复旦大学化学系,博士

2010.8-2011.8 GlaxoSmithkline, HIV DPU, RTP, USAIntern

2012.7-2014.6 复旦大学生物医学研究院,博士后

2014.7-2017.7 复旦大学药学院,博士后

2014.7-2019.5 The Scripps Research Institute, Jupiter, FL, USA, Research Associate

2019.6-2020.4 中国科学院上海药物研究所,特别研究助理

2020.5-至今, 福建师范大学,南方生物医学研究中心,研究员


CellACS CatPNASJ Med Chem等国际著名杂志发表SCI论文25篇,其中一作/共一/共通讯13篇。获得授权国际/美国专利1项和中国专利2项;主持国自然青年基金和博士后基金等项目2项;


研究方向:

1)基于蛋白结构的药物分子设计与合成,靶向BPTFLSD1CDK家族、小G蛋白RhoATEAD等新型分子探针或先导化合物的选择性、活性和成药性优化。

2)针对核激素受体ERRαERRβERRγPGC1αPPARγGR等,离子通道和激酶等目标靶点设计合成具有体外和体内生物活性的药物分子, 用于治疗性治疗糖尿病、肥胖症和睡眠等相关疾病。(J Med Chem 2018; WO/2019/108739; U.S. Application No. 62/590,736.);

3)开发新的碳氢活化方法学,用于合成重要的天然产物、药物分子,并应用于药物分子在最后的合成阶段进行官能团转化,如两步合成已上市年销售额25亿美元的免疫抑制药物Gilenya (Chem Eur J 2018; ACS Cat 2019)

4)开发新的手性合成方法学高效合成手性合成砌块,应用于天然产物和药物分子的合成。已开发了双有机小分子协同催化的多组分不对称串联反应合成手性多取代手性杂环化合物的方法。所合成的化合物具有良好的抗老年痴呆症和疟疾活性(Org Lett 2012; Chem Commun 2013; Org Lett 2014)


论文和专利

  1. Erica J. Young, Hua Lin, Theodore M. Kamenecka, Gavin Rumbaugh,* and Courtney A. Miller* The Journal of Neuroscience, 2020, 40, 2695–2707.

  2. Hua Lin, Xiaohong Pan, Adam L. Barsamian, Theodore M. Kamenecka, Thomas D. Bannister*, ACS Catalysis, 2019, 4887-4891.

  3. Hua Lin, Chao Wang, Thomas D. Bannister, Theodore M. Kamenecka*, Chemistry–A European Journal, 2018, 24, 9535-9541.

  4. Hua Lin, Jonathan Z. Long, Alexander M. Roche, Katrin J. Svensson, Florence Dou, Mi Ra Chang, Timothy Strutzenberg, Claudia Ruiz, Michael D. Cameron, Scott J. Novick, Charles M. Berdan, Sharon Louie, Daniel K. Nomura, Bruce M. Spiegelman, Patrick R. Griffin, Theodore M. Kamenecka*, Journal of Medicinal Chemistry, 2018, 61, 3224-3230.

  5. Hua Lin, Christelle Doebelin, Rémi Patouret, Ruben D. Garcia-Ordonez, Mi Ra Chang, Venkatasubramanian Dharmarajan, Claudia Ruiz Bayona, Michael D. Cameron, Patrick R. Griffin, Theodore M. Kamenecka*, Bioorganic & Medicinal Chemistry Letters, 2018, 28, 1313-1319.

  6. Jinsai Shang, Richard Brust, Sarah A. Mosure, Jared Bass, Paola Munoz-Tello, Hua Lin, Travis S. Hughes, Miru Tang, Qingfeng Ge, Theodore M. Kamenekca, Douglas J. Kojetin*,  eLife, 2018, 7:e43320.

  7. Jonathan Z. Long, Alexander M. Roche, Charles A. Berdan, Sharon M. Louie, Amanda J. Roberts, Katrin J. Svensson, Florence Y. Dou, Leslie A. Bateman, Amir I. Mina, Zhaoming Deng, Mark P. Jedrychowski, Hua Lin, Theodore Kamenecka, John M. Asara, Patrick R. Griffin, Alexander S. Banks, Daniel K. Nomura, Bruce M. Spiegelman*, PNAS, 2018, 2018, 115, E6937–E6945.

  8. Richard Brust,Hua Lin, Jakob Fuhrmann, Alice Asteian, Theodore M. Kamenecka, and Douglas J. Kojetin*, ACS chemical biology, 2017, 12, 969-978. (共同第一)

  9.  Kfir Sharabi, Hua Lin, Clint D. J. Tavares, John E. Dominy, Roger Schilling, Amy K. Rines, Marc Hickey, Melissa Bennion, Partha P. Nag, José Perez, Mark P. Jedrychowski, Steve P. Gygi, Theodore M. Kamenecka, Stuart L. Schreiber, Patrick R. Griffin and Pere Puigserver*, Cell, 2017, 169, 148-160.

  10. Yu Tan, Er-Lu Feng, Qiang-Sheng Sun, Hua Lin*, Xun Sun, Guo-Qiang Lin, and Xing-Wen Sun*, Organic & Biomolecular Chemistry, 2017, 15, 778 (cover article). (*共同通讯)

  11. Zhuang Jin, Hua Lin, Sathish Srinivasan, Jerome C Nwachukwu, Nelson E Bruno, Patrick R Griffin, Kendall W Nettles*, Theodore Kameneck*, Bioorganic & Medicinal Chemistry Letters, 2017, 27, 347.

  12. Jonathan Z. Long, Katrin J. Svensson, Leslie A. Bateman, Hua Lin, Theodore Kamenecka, Isha A. Lokurkar, Jesse Lou, Rajesh R. Rao, Mi Ra Chang, Mark P. Jedrychowski, Joao A. Paulo, Steven P. Gygi, Patrick R. Griffin, Daniel K. Nomura*, Bruce M. Spiegelman*, Cell, 2016, 166, 424–435.

  13.  Qiang-Sheng Sun, Hua Zhu, Hua Lin*, Yu Tan, Xiao-Di Yang, Xing-Wen Sun*, Xun Sun, Tetrahedron Letters, 2016, 57, 5768. (*共同通讯)

  14.  Qiang-Sheng Sun, Hua Lin*, Xun Sun, Xing-Wen Sun*, Tetrahedron Letters, 2016, 57, 5673. (*共同通讯)

  15.  Sarbani Ghoshal, Qingzhang Zhu, Alice Asteian,Hua Lin, Haifei Xu, Glen Ernst, James C Barrow, Baoji Xu, Michael D Cameron, Theodore M Kamenecka, Anutosh Chakraborty*, Molecular Metabolism,2016, 5, 903–917.

  16. Hua Lin, Yu Tan, Jian-Ming Wu, Xiao-Di Yang*, Jun-Hua Chen, Xing-Wen Sun*, Tetrahedron Letters,2015, 56, 913.

  17. Qiang-Sheng Sun, Xiao-Yang Chen, Hua Zhu, Hua Lin, Xing-Wen Sun* and Guo-Qiang Lin, Organic Chemistry Frontiers, 2015, 2, 110.

  18. Hua Lin, Xing-Wen Sun*, Guo-Qiang Lin, Organic Letters, 2014, 16, 752.

  19. Yu Tan, Yong-Jian Chen, Hua Lin, Han-Lin Luan, Xing-Wen Sun,* Xiao-Di Yang and Guo-Qiang Lin*, Chemical Communications, 2014, 50, 15913.

  20. Yu Tan, Han-Lin Luan, Hua Lin, Xing-Wen Sun*, Xiao-Di Yang, Han-Qing Dong and Guo-Qiang Lin*, Chemical Communications, 2014, 50, 10027.

  21. Hua Lin, Yu Tan, Wen-Jie Liu, Zhi-Cheng Zhang, Xing-Wen Sun*, Guo-Qiang Lin*, Chemical Communications,2013, 49, 4024.

  22. Hua Lin, Yu Tan, Xing-Wen Sun*, Guo-Qiang Lin*, Organic Letters, 2012, 14, 3818.

  23. Hua Lin, Yang Zang, Ru-Lin Ma, Xing-Wen Sun*, Guo-qiang Lin*, Chinese Journal of Chemistry,2012, 30, 2309.

  24. Hua Lin, Kyong-Sung Han, Xing-Wen Sun*, Guo-Qiang Lin*, Chinese Journal of Organic Chemistry, 2008, 28, 1479.

  25. Hua Lin, Xing-Wen Sun*, Tetrahedron Letters,2008, 49, 5343.

已授权专利

  1. Bruce M. Spiegelman, Jonathan Z. Long, Hua Lin, Theodore M. Kamenecka, Patrick R. Griffin, Chemical Uncouplers of Respiration and Methods of Use Thereof, Pub. No.: WO/2019/108739.

  2. 林国强,孙兴文,林华,沈少春,臧扬,一种制备不对称双吲哚甲烷类化合物的方法,专利号:ZL 200910053428.1

  3. 林国强,孙兴文,林华,沈少春,臧扬,李榕,钟毅,马伟伟,具有生物活性双吲哚甲烷类化合物,专利号:ZL 200910053430.9

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