陈 骐






福建师范大学生命科学学院,南方生物医学研究中心

电话:(0591)-22868190   

Email: nfsw@fjnu.edu.cn

个人简介

男,教授,博士生导师。现任福建省天然免疫生物学重点实验室主任,南方生物医学研究中心副主任。福建师范大学学术委员会委员。

2012年度福建省高校领军人才资助人选。


教育经历:

 1981/09-1985/06 福建师范大学 学士

 1985/09-1988/06 中国农业科学院 硕士

 1988/09-1992/10 中国农业科学院 博士

 1994/02-1999/08  University of Southern California 博士


工作经历:

 1985/08-1989/08 中国农业科学院分子生物学研究室

 1988/07-1992/07 中国农业科学院生物技术研究中心

 1989/09-1992/06 Rutgers UniversityResearch Associate

 1992/07-1994/02 中国农业科学院助理研究员

 1999/09-2006/06  The Salk Institute for Biological Studies博士后

 2006/07-2009/12  The Salk Institute for Biological StudiesSenior Research Associate

 2010/1-2012/12-  The Blanchette Rockefeller Neurosciences Institute at WVU  Assistant Professor

 2012/09至今  福建师范大学南方生物医学研究中心  教授


研究方向:

 1、疾病的免疫调控机制研究。2、基因分子诊断及精准医学。3CRISPR/Cas9基因修饰技术的开发应用。4、抗体及免疫细胞治疗。5、动物胚胎工程及疫病防治。6、小分子化学药物的研究开发。


成果奖励

 中国农业部科学进步三等奖, 1991年 参与人员

 The Pioneer Fund Fellowship,2000年9月至2001年8月

 The Bundy Foundation Fellowship,1999年9月至2006年6月

 王宽诚基金留学访问学者奖励基金(三次),中国科学院生物物理研究所,合作及邀请人--赵保路研究员,2001年、2003 年及2005年

 Reagan-Thal Legacy Award, 2008

 2012年,入选福建省高校领军人才


论文著作:

 [1] Nanyang Xiao, Jingjing Wei, Shan Xu, Hekang Du, Miaohui Huang, Sitong Zhang, Lijun Sun*, Qi Chen*. cGAS Is Responsible for Spontaneous Lupus-Like Autoinmune Disorder Induced by TREX1 Mutation. J of Autoimmunity. https://doi.org/10.1016/j.jaut.2019.03.001.

  [2] Qianping Luo, Koteswara Rao Bandib, Yanqiu Dong, Hongli Bao, Daliang Li*, Qi Chen*. Synthesis and living cell imaging of a novel fluorescent sensor for selective cupric detection.  Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. https://doi.org/10.1016/j.saa.2019.02.013. 2019.

  [3] Bo Zhang, Weiwei Ye, Yangmiao Ye, Huan Zhou, Abdullah F. U. H. Saeed, Jing Chen, Jinying Lin, Vanja Perčulija, Qi Chen, Chun-Jung Chen, Ming-Xian Chang, Muhammad Iqbal Choudhary & Songying Ouyang.Structural insights into Cas13b-guided CRISPR RNA maturation and recognition.  Cell Research 2018.

  [4] Haitao Niu, Feng Li, Qingshui Wang, Zhoujie Ye, Qi Chen* and Yao Lin*. High expression level of MMP9 is associated with poor prognosis in patients with clear cell renal carcinoma.  Peer J 6:e5050. 2018.

  [5] Qianping Luo, Yong Fan, Lili Lin, Jingjing Wei, Zuanfang Li, Yongkun Li, Susumu Nakae, Wei Lin and Qi Chen*. Interleukin-33 Protects Ischemic Brain Injury by Regulating Specific Microglial Activities. Neuroscience 385: 75-89, 2018.

 [6] Yong Fan, Qianping Luo, Jingjing Wei,Ruhui Lin, Lili Lin, Yongkun Li, Zhaorong Chen, Wei Lin, Qi Chen*.Mechanism of Salvianolic Acid B Neuroprotection against Ischemia/Reperfusion Induced Cerebral Injury.Brain Research 2017, doi.org/10.1016/j.brainres.2017.11.027.

 [7] Junzhong Lai, Hanze Wang, Qianping Luo, Shanlu Huang, Shujin Lin, Yansong Zheng, and Qi Chen*.The relationship between DNA methylation and Reprimo gene expression in gastric cancer cells.Oncotarget 2017,doi.org/10.18632/oncotarget.21296.

 [8] Lixia Liu, Xiuqin Wu, Bingchen Zhang, Wei Yang, Yujiao Yin, Qi Chen*.Protective Effects of Tea Polyphenols on Exhaustive Exercise-Induced Fatigue, Inflammation and Tissue Damage.Food Nutr Res 2017, 61(1):1333390.  doi: 10.1080/16546628.2017.1333390.

 [9] Hanze Wang, Huican Ke, Junzhong Lai, Yansong Zheng, Qianping Luo, Qi Chen*. A Modified Bisulfite Conversion Method for the Detection of DNA Methylation.Epigenetics 2017, 9 (7) :955-969.  doi:10.2217/epi-2016-0174.

 [10] Hui Yang, Hanze Wang, Junyao Ren, Qi Chen,and Zhijian J. Chen.cGAS is Essential for Cellular Senescence.Proc Nat Acad Sci USA 2017, 114 (23) :E4612-E4620.doi:10.1073/pnas.1705499114.

 [11] Jingqian Su, Huiying Liu, Kai Guo, Long Chen, Minhe Yang and Qi Chen*.Research Advances and Detection Methodologies for Microbe-Derived Acetylcholinesterase Inhibitors: A Systemic Review.Molecules 2017, 22(1). doi:10.3390/molecules22010176. 

 [12]Qi Chen,Lijun Sun, Zhijian J Chen. Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing.Nature Immunology 2016,17(10): 1142-1149.

 [13]Hanze Wang, Yansong Zheng, Junzhong Lai, Qianping Luo, Huican Ke, Qi Chen*.Methylation-Sensitive Melt Curve Analysis of the Reprimo Gene Methylation in Gastric Cancer.PLoS One DOI:10.1371/journal.pone.0168635 December 16, 2016.

 [14]Qi Chen, Marguerite Prior, Richard Dargusch, Amanda Roberts, Roland Riek, Ce´ dric Eichmann, Chandramouli Chiruta, Tatsuhiro Akaishi, Kazuho Abe, Pamela Maher, David Schubert*. A Novel Neurotrophic Drug for Cognitive Enhancement and Alzheimer's Disease.PLoS One 2011,6(12):1-17.

 [15] Federico Herrera, Qi Chen, and David Schubert.Synergistic effect of retinoic Acid and cytokines on the regulation of glial fibrillary acidic protein expression.Journal of Biological Chemistry 2010,285(50):38915-38922

 [16] Xianjin Zhou, Qi Chen,Katie Schaukowitch, John R Kelsoe, and Mark A Geyer.Insoluble DISC1-Boymaw Fusion Proteins Generated by the DISC1 Translocation. Molecular Psychiatry 2010, 15(7): 670–672

 [17] Qi Chen, Charles A. Peto, G. Diane Shelton, Andrew Mizisin,Paul E. Sawchenko,and David Schubert.Loss of MOCA reveals a pathway leading to axonal degeneration.Journal of Neurosciences 2009,29(1):118 –130

 [18] Joseph R. Burdo, Qi Chen, Nigel A. Calcutt, David Schubert∗. The pathological interaction between diabetes and presymptomatic Alzheimer’s disease. Neurobiology of Aging 2009,1910–1917

 [19] Federico Herrera, Qi Chen,Wolfgang H.Fischer, Pamela Maher, and David Schubert*.Synaptojanin-1 plays a key role in astrogliogenesis: possible relevance for Down’s syndrome.Cell Death and Differentiation 2009, 16(6): 910–920