李达谅

    Email：daliangli@fjnu.edu.cn  或lidlbhl@163.com;

    地址：福建省福州市闽侯上街福建师范大学旗山校区理工楼13#南604

    QQ: 11274791

个人简介：男，福建泉州人，教授

教育经历：1996年9月至2005年7月，中国科学技术大学化学系学习，先后获得化学学士学位和有机化学博士学位

工作经历：

       2005年7月至2007年7月，上海有机化学研究所生命有机国家重点实验室博士后研究；

       2007年8月至2014年，美国得州大学西南医学中心，博士后、Instructor、Research  Scientist；

       2014年9月至今，福建师范大学生命科学学院工作；

研究方向：应用化学或生物探针研究细胞行为及在糖尿病、癌症诊断治疗中的作用等；天然产物的提取及生物学研究；

成果及奖励：近年来，先后参与国家自然科学基金重点项目1项、主持教育部留学归国人员科研启动基金项目1项和福建省自然科学基金面上项目1项，参与”福建省天然免疫生物学重点实验室“建设项目等多项科研课题；在《Proc.  Natl. Acad. Sci. USA》、《ACS Chem. Biol.》、《Bioconjugate  Chem  》等刊物上以第1作者(或通讯作者)发表多篇论文，其他SCI论文10篇（与他人合作）；  另有美国/国际授权一份。

教学：担任本科生《化学系列实验》、《天然产物与药物化学》等课程主讲任务。

获奖：

        福建省引进高层次人才C类（国外）

        福建师范大学“高层次引进人才”计划

硕士生招生方向：生物化学与分子生物学、遗传学和有机化学等。

论文专利：

1.      Kaikai Wang, Shaowei Chen, Yajun Li, Daliang Li*, and Hongli Bao*, Iron-Catalyzed Decarboxylative Heck-Type Alkylation of Conjugate 1,3-Dienes, Chinese Journal of Organic Chemistry, Volume 32, Issue 214, 107904, July 2020.

2.      Gao, Y.*, Chen, Z., Yao, W., Li, D., Fu, X*. Gentamicin combined with hypoionic shock rapidly eradicates aquaculture bacteria in vitro and in vivo, Frontiers in Microbiology，2021, accepted, https://www.frontiersin.org/articles/10.3389/fmicb.2021.641846/

3.      叶佳慧，张悦，黄梦婷，陈敏，黄争荣*，李达谅*，抗炎活性单方中草药的免疫活性研究现状，海峡药学，2021，2期，

4.      寇盟，蔡幸婷，李达谅*，基于cGAS-STING信号通路调控小分子化合物的研究进展，福建轻纺，2021，2期，

5.      Junzhong Lai, Yajuan Fu, Shuoran Tian, Shanlu Huang, Xuan Luo, Lili Lin, Xing Zhang, Hanze Wang, Zhang Lin, Heng Zhao, Shujin Lin, Junhong Zhao, Shan Xu, Daliang Li, Shaoli Cai, Luna Dong, Jing Qian, Jiadi Liang, Qiumei Li, Yong Zhang, Jiqiang Fan, Robert Balderas, Qi Chen*. Zebularine elevates STING expression and enhances cGAMP cancer immunotherapy in mice. Molecular therapy, 2021 Feb 9; S1525-0016(21)00072-1.  doi: 10.1016/j.ymthe.2021.02.005. Online ahead of print.

6.      Ebrahim H. Ghazvini Zadeh, Zhijiang Huang, Jing Xia, Daliang Li, Howard W. Davidson, Wen-hong Li, ZIGIR, a Granule-Specific Zn²⁺ Indicator, Reveals Human Islet α Cell Heterogeneity, CellReports, Volume 32, Issue 214, 107904, July 2020.

7.      Yixuan Liu^#, Nanyang Xiao^#, Hekang Du, Meng Kou,Lili Lin, Min Huang, Sitong Zhang, Shan Xu, Daliang Li^*, and Qi Chen^*, Celastrol Ameliorates Autoimmune Disorders in Trex1-deficient Mice,  Biochemical Pharmacology, Volume 178, August 2020, 114090

8.      Hongxin Guan^#, Youwang Wang^#, Ting Yu^#, Yini Huang^#, Mianhuan Li, Abdullah F. U. H. Saeed, Vanja Perčulija, Daliang Li, Jia Xiao, Dongmei Wang, Ping Zhu*, Songying Ouyang*, Cryo-EM structures of the human PA200 and PA200-20S complex reveal regulation of proteasome gate opening and two PA200 apertures, PLOS Biology,  published 05 Mar 2020 PLOS Biology, 18(3):e3000654 (https://doi.org/10.1371/journal.pbio.3000654 )

9.      Linye Wu, Langjun Chen, Meng Kou, Yanqiu Dong, Weili Deng, Liang Ge, Hongli Bao, Qi Chen*, Daliang Li*, The ratiometric fluorescent probes for monitoring the reactive inorganic sulfur species (RISS) signal in the living cell, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, https://doi.org/10.1016/j.saa.2020.118141. 231 (2020) 118141.

10.  陈朗军，吴林烨，李达谅*，肽核酸单体的合成进展及其在肿瘤医学研究中的应用，福建轻纺，2019，12期，17-23.

11.  Jingqian Su, Kai Guo, Jie Zhang, Min Huang, Lijun Sun, Daliang Li, Ka-Lai Pang, Guangce Wang, Long Chen, Zhiyu Liu, Youqiang Chen* , Qi Chen* and Luqiang Huang* ，Fucoxanthin, a marine xanthophyll isolated from Conticribra weissflogii ND-8: preventive anti-inflammatory effect in a mouse model of sepsis，Front. Pharmacol. ，2019，DOI: 10.3389/fphar.2019.00906

12.  Qianping Luo#, Koteswara Rao Bandi#, Yanqiu Dong, Hongli Bao, Daliang Li* and Qi Chen*. Synthesis and living cell imaging of a novel fluorescent sensor for selective cupric detection. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2019, 214, 146-151.  

13.    Weili Deng, Changqing Ye, Yajun Li, Daliang Li* and Hongli Bao*. Iron-Catalyzed Oxyalkylation of Terminal Alkynes with Alkyl Iodides.Org. lett. 2019, 21, 261-265.

14.   Changqing Ye, Bo Qian, Yajun Li, Min Su, Daliang Li*, and Hongli Bao*，Iron-Catalyzed Dehydrative Alkylation of Propargyl Alcohol with Alkyl Peroxides To Form Substituted 1,3-Enynes, Org. Lett. 2018, 20 (11), 3202–3205.

15.   Zhou, Huan; Jian, Wujun; Qian, Bo; Ye, Changqing ; Li, Daliang; Zhou, Jing; Bao, Hongli*，Copper-Catalyzed Ligand Free Diazidation of Olefins with TMSN3 in CH3CN or in H2O, Org. Lett. 2017, 19 (22), 6120-6123.

16.   Lixia Liu, Xiuqin Wu, Bingchen Zhang, Wei Yang, Daliang Li, Yanqiu Dong, Yujiao Yin & Qi Chen, Protective effects of tea polyphenols on exhaustive exercise-induced fatigue, inflammation and tissue damage, Food & Nutrition Research, 2017, 61 (1) : 1333390.

17.   Wujun Jian, Bo Qian, Hongli Bao*, Daliang Li*, AlCl3 catalyzed oxa-Diels-Alder reaction of aromatic aldehydes with simple dienes, Tetrahedron, 2017, 73（29）, 4039-4044.

18.   Yan Xu, Yan Chen, Daliang Li, Qing Liu, Zhenyu Xu, Wen-hong Li, TargetLink, a new method for identifying the endogenous target set of a specific microRNA in intact living cells, RNA Biology, 2017, 14(2), 259-274.

19.   Daliang Li#, Lin Liu#, Wen-hong Li*, Genetic targeting of a small fluorescent zinc indicator to cell surface for monitoring zinc secretion，ACS Chem. Biol., 2015, 10 (4), 1054-1063.

20.   Daliang Li, ZhiJiang Huang, Shiuhwei Chen, Wen-hong Li*, GLP-1 receptor mediated targeting of a fluorescent Zn2+ sensor to beta cell surface for imaging insulin/Zn2+ release, Bioconjugate Chem., 2015, 26 (8), 1443-1450.

21.   Wen-hong Li*, Daliang Li, FLUORESCENT PROBES FOR MONITORING REGULATED SECRETION,Curr. Opin. Chem. Biol.,2013, 17(4), 672-681.

22.   Hodson, David; Mitchell, Ryan; Marselli, Lorella; Pullen, Timothy; Gimeno Brias, Silvia; Semplici, Francesca; Everett, Katy; Cooper, Dermot; Bugliani, Marco; Marchetti, Piero; Lavallard, Vanessa; Bosco, Domenico; Piemonti, Lorenzo; Johnson, Paul; Hughes, Stephen; Li, Daliang; Li, Wen-hong; Shapiro, A.M.; Rutter, Guy*, ADCY5 couples glucose to insulin secretion in human islets, Diabetes, 2014, 63: 3009-3021.

23.   David J. Hodson*, Ryan K. Mitchell, Elisa A. Bellomo, Gao Sun, Laurent Vinet, Paolo Meda, Daliang Li, Wen-Hong Li,  Marco Bugliani, Piero Marchetti, Domenico Bosco, Lorenzo Piemonti, Paul Johnson, Stephen J. Hughes, and Guy A. Rutter*, Lipotoxicity disrupts incretin-regulated human β cell connectivity, J. Clin. Invest., 2013, 123(10), 4182-4194.

24.   Wen-Hong Li*, Daliang Li, ZINC SENSOR FOR CELLULAR IMAGING, US2012009617 (A1)；WO 2011/156728 A2; US 8,530,183 B2.

25.   Andrei I. Tarasov, Francesca Semplici, Daliang Li, Rosario Rizzuto, Magalie A. Ravier, Patrick Gilon, and Guy A. Rutter*,Frequency-dependent Ca2+ accumulation regulates mitochondrial ATP synthesis in pancreatic b-cells, PFLUG ARCH EUR J PHY, 2013, 465(4), 543-554

26.   Daliang Li#, Shiuhwei Chen#, Elisa A. Bellomo, Callan Kaut, Guy A. Rutter and Wen-hong Li*, Imaging dynamic insulin release using a fluorescent zinc indicator for monitoring induced exocytotic release (ZIMIR),  Proc. Natl. Acad. Sci. USA, 2011, 108 (52),21063-21068.

27.   Chen Jiang, Daliang Li, Jiwu Wen, Tianpa You*, QSAR study of the enantiomeric excess in asymmetric catalytic reactions with topological indices and an artificial neural network, J. Mol. Model., 2007, 13(1), 91-97

28.   Daliang Li, Hongli Bao, Qitao Tan, Dongmei Cai, Tianpa You*, Synthesis of ribavirin analogues containing amino acids residues, Synth. Commun.,2005, 35(8), 1017-1025.

29.   Daliang Li, Hongli Bao, Qitao Tan, Yuping Ke, Tianpa You*, Synthesis and Biological Evaluation of a New  Category of Purine-nucleoside Analogues, Chin. J. Chem.,2005, 23 (12), 1659-1664.

30.   Daliang Li, Hongli Bao, Tianpa You*, Microwave-assisted and efficient one-pot synthesis of substituted 1,2,4-triazoles, Heterocycles, 2005, 65(8), 1957-1962.

31.   Qitao Tan, Jiwu Wen, Daliang Li, Hongyan Li, Tianpa You*, Novel Bis(oxazoline) Ligands Derived from Camphoric Acid for Cu-catalyzed Asymmetric Cyclopropanation, J. Mol. Catal. A: Chem., 2005, 242 (1-2), 113-118.

32.   Qitao Tan, Daliang Li, Hongli Bao, Yunying Wang, Jiwu Wen, Tianpa You*, A Convenient Preparation of Enantiopure endo-2-Hydroxyepicamphor and endo-3-Hydroxycamphor from Camphoric Acid, Synth. Commun.,2004, 34, 2945

33.   Dongmei Cai, Minjie Li, Daliang Li, Tianpa You*, Synthesis of C-Nucleoside Analogues: 2-[2-(hydroxymethyl)-1,3-dioxolan-5-yl]-1,3-thiazole-4-carboxamide and 2-[2-mercaptomethyl]-1,3-Dioxo-lan- 5-yl]-1,3-thiazole-4-carboxamide, Chin. Chem. Lett., 2004, 15(2), 163-166.

34.   Qitao Tan, Yunying Wang, Daliang Li, Jiwu Wen, Tianpa You*, A Novel and Efficient Synthesis of Camphorquinone from Camphoric Acid, Synthesis, 2003, 1869.

35.   Changsheng Jiang, Daliang Li, Qingfang Cheng, Yuping Ke, Tianpa You*, Asymmetric Reformastky Reaction Catalyzed by the Derivatives of Amino Acid, Chemistry(Chinese), 2001, 637-640.

目前主持及参与的基金：

1、福建师范大学校创新团队“基于天然免疫的化学免疫学研究”（IRTL1703）——主持

2、另主持福建省自然科学基金一项及教育部留学归国人员科研启动基金一项；参与国家自然科学基金面上一项（烷基过氧酰化合物--烯烃炔烃的新型烷基化试剂，201721672213）

3、曾参与国家自然科学基金重点项目（环肽类天然产物的合成和作用机制演技，20632050，已结题）一项。