陈 骐

个人简介：

男，教授，博士生导师。现任福建省天然免疫生物学重点实验室主任，南方生物医学研究中心副主任。福建师范大学学术委员会委员。

2012年度福建省高校领军人才资助人选。

教育经历：

 1981/09-1985/06 福建师范大学 学士

 1985/09-1988/06 中国农业科学院 硕士

 1988/09-1992/10 中国农业科学院 博士

 1994/02-1999/08  University of Southern California 博士

工作经历：

 1985/08-1989/08 中国农业科学院分子生物学研究室

 1988/07-1992/07 中国农业科学院生物技术研究中心

 1989/09-1992/06 Rutgers UniversityResearch Associate

 1992/07-1994/02 中国农业科学院助理研究员

 1999/09-2006/06  The Salk Institute for Biological Studies博士后

 2006/07-2009/12  The Salk Institute for Biological StudiesSenior Research Associate

 2010/1-2012/12-  The Blanchette Rockefeller Neurosciences Institute at WVU  Assistant Professor

 2012/09至今  福建师范大学南方生物医学研究中心  教授

研究方向：

 1、疾病的免疫调控机制研究。2、基因分子诊断及精准医学。3、CRISPR/Cas9基因修饰技术的开发应用。4、抗体及免疫细胞治疗。5、动物胚胎工程及疫病防治。6、小分子化学药物的研究开发。

成果奖励：

 中国农业部科学进步三等奖, 1991年 参与人员

 The Pioneer Fund Fellowship，2000年9月至2001年8月

 The Bundy Foundation Fellowship，1999年9月至2006年6月

 王宽诚基金留学访问学者奖励基金(三次)，中国科学院生物物理研究所，合作及邀请人--赵保路研究员，2001年、2003 年及2005年

 Reagan-Thal Legacy Award, 2008年

 2012年，入选福建省高校领军人才

论文著作：

[1] Junzhong Lai, Yajuan Fu, Shuoran Tian, Shanlu Huang, Xuan Luo, Lili Lin, Xing Zhang, Hanze Wang, Zhang Lin, Heng Zhao, Shujin Lin, Junhong Zhao, Shan Xu, Daliang Li, Shaoli Cai, Luna Dong, Jing Qian, Jiadi Liang, Qiumei Li, Yong Zhang, Jiqiang Fan, Robert Balderas, Qi Chen. Zebularine elevates STING expression and enhances cGAMP cancer immunotherapy in mice. Molecular therapy. 2021 Feb 9; S1525-0016(21)00072-1.  doi: 10.1016/j.ymthe.2021.02.005. Online ahead of print.

[2] Lixia Liu, Yingyong Zhang, Tao Liu，Chongrong Ke, Jianzhong Huang, Yajuan Fu, Zhang Lin, Fengjuan Chen, Xiuqin Wu, Qi Chen*. Pyrroloquinoline Quinone Protects against Exercise-induced Fatigue and Oxidative Damage via Improving Mitochondrial Function in Mice. FASEB J. January 2021. https://10.1096/fj.202001977RR. 

[3] Shuoran Tian, Junzhong Lai, Tingting Yu, Qiumei Li and Qi Chen*.   Regulation of Gene Expression Associated With the N6-Methyladenosine (m6A) Enzyme System and Its Significance in Cancer. Front. Oncol., 21 January 2021. https://doi.org/10.3389/fonc.2020.623634.

[4] Yajuan Fu, Liqun Zheng, Zhang Lin, Jiaoxia Zeng, Suxing Chen, Junhong Zhao, Yijun Fang, Hao Hu, Hanze Wang, Wei Bao, Qi Chen*, Lijun Sun*. Inhibition of cGAS-mediated interferon response facilitates transgene expression. iSCIENCE, doi: https://doi.org/10.1016/j.isci.2020.101026, 2020. 

[5] Zhihua Feng, Jianghua Chen, Wangwang Liang, Wenzhi Chen, Zhaolong Li, Qi Chen & Shaoli Cai The recombinant pseudorabies virus expressing African swine fever virus CD2v protein is safe and effective in mice. Virol J 17, 180 (2020). https://doi.org/10.1186/s12985-020-01450-7.

[6] Lin J, Li Z, Feng Z, Fang Z, Chen J, Chen W, Liang W, Chen Q. Pseudorabies virus (PRV) strain with defects in gE, gC, and TK genes protects piglets against an emerging PRV variant. J Vet Med Sci. 2020 Jun 30;82(6):846-855. doi: 10.1292/jvms.20-0176. Epub 2020 Apr 24.

[7] Yixuan Liu, Nanyang Xiao, Hekang Du, Meng Kou, Min Huang, Lili Lin, Shan Xu, Daliang Li &, and Qi Chen*. Celastrol Ameliorates Autoimmune Disorders in Trex1-deficient Mice. Biochemical Pharmacology. 10.1016/j.bcp.2020.114090. 2020.  

[8]  Kai Wang, Kun Man, Jiafeng Liu, Yang Liu, Qi Chen, Yong Zhou, Yong Yang. Microphysiological Systems: Design, Fabrication and Applications. ACS Biomaterials Science & Engi.

[9] Lai J, Luo X, Tian S, Zhang X, Huang S, Wang H, Li Q, Cai S and Chen Q*. Compound C Reducing Interferon Expression by Inhibiting cGAMP Accumulation. Front. Pharmacol. 11:88. doi: 10.3389/fphar.2020.00088. Feb. 28, 2020.

[10] Linye Wu, Langjun Chen, Meng Kou, Yanqiu Dong, Weili Deng, Liang Ge, Hongli Bao, Qi Chen*, Daliang Li*. The ratiometric fluorescent probes for monitoring the reactive inorganic sulfur species (RISS) signal in the living cell. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. https://doi.org/10.1016/j.saa.2020.118141. Feb. 7, 2020.

[11] Yuanji Xu, Jiling Wang, Shaoli Cai, Guanghao Chen, Nanyang Xiao, Yajuan Fu, Qi Chen, Sufang Qiu. PNCK depletion inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells in vitro and in vivo. J Cancer 2019; 10(27):6925-6932. doi:10.7150/jca.33698.

[12] Su, Jingqian; Guo, Kai; Huang, Min; Liu, Yixuan; Zhang, Jie; Sun, Lijun; Li, Daliang; Pang, Ka-Lai; Wang, Guangce; Chen, Long; Chen, Youqiang*; Chen Qi*, and Huang, Luqiang*. Fucoxanthin, a Marine Xanthophyll Isolated From Conticribra weissflogii ND-8: Preventive Anti-Inflammatory Effect in a Mouse Model of Sepsis. August 2019, Frontiers in Pharmacology 10. DOI: 10.3389/fphar.2019.00906.

[13] Nanyang Xiao, Jingjing Wei, Shan Xu, Hekang Du, Miaohui Huang, Sitong Zhang, Lijun Sun*, Qi Chen*. cGAS Is Responsible for Spontaneous Lupus-Like Autoinmune Disorder Induced by TREX1 Mutation. J of Autoimmunity. https://doi.org/10.1016/j.jaut.2019.03.001.

[14] Qianping Luo, Koteswara Rao Bandib, Yanqiu Dong, Hongli Bao, Daliang Li*, Qi Chen*. Synthesis and living cell imaging of a novel fluorescent sensor for selective cupric detection.  Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. https://doi.org/10.1016/j.saa.2019.02.013. 2019.

[15] Bo Zhang, Weiwei Ye, Yangmiao Ye, Huan Zhou, Abdullah F. U. H. Saeed, Jing Chen, Jinying Lin, Vanja Perčulija, Qi Chen, Chun-Jung Chen, Ming-Xian Chang, Muhammad Iqbal Choudhary & Songying Ouyang.Structural insights into Cas13b-guided CRISPR RNA maturation and recognition.  Cell Research 2018.

[16] Haitao Niu, Feng Li, Qingshui Wang, Zhoujie Ye, Qi Chen* and Yao Lin*. High expression level of MMP9 is associated with poor prognosis in patients with clear cell renal carcinoma.  Peer J 6:e5050. 2018.

[17] Qianping Luo, Yong Fan, Lili Lin, Jingjing Wei, Zuanfang Li, Yongkun Li, Susumu Nakae, Wei Lin and Qi Chen*. Interleukin-33 Protects Ischemic Brain Injury by Regulating Specific Microglial Activities. Neuroscience 385: 75-89, 2018.

[18] Yong Fan, Qianping Luo, Jingjing Wei,Ruhui Lin, Lili Lin, Yongkun Li, Zhaorong Chen, Wei Lin, Qi Chen*.Mechanism of Salvianolic Acid B Neuroprotection against Ischemia/Reperfusion Induced Cerebral Injury.Brain Research 2017, doi.org/10.1016/j.brainres.2017.11.027.

[19] Junzhong Lai, Hanze Wang, Qianping Luo, Shanlu Huang, Shujin Lin, Yansong Zheng, and Qi Chen*.The relationship between DNA methylation and Reprimo gene expression in gastric cancer cells.Oncotarget 2017,doi.org/10.18632/oncotarget.21296.

[20] Lixia Liu, Xiuqin Wu, Bingchen Zhang, Wei Yang, Yujiao Yin, Qi Chen*.Protective Effects of Tea Polyphenols on Exhaustive Exercise-Induced Fatigue, Inflammation and Tissue Damage.Food Nutr Res 2017, 61(1):1333390.  doi: 10.1080/16546628.2017.1333390.

[21] Hanze Wang, Huican Ke, Junzhong Lai, Yansong Zheng, Qianping Luo, Qi Chen*. A Modified Bisulfite Conversion Method for the Detection of DNA Methylation.Epigenetics 2017, 9 (7) :955-969.  doi:10.2217/epi-2016-0174.

[22] Hui Yang, Hanze Wang, Junyao Ren, Qi Chen,and Zhijian J. Chen.cGAS is Essential for Cellular Senescence.Proc Nat Acad Sci USA 2017, 114 (23) :E4612-E4620.doi:10.1073/pnas.1705499114.

[23] Jingqian Su, Huiying Liu, Kai Guo, Long Chen, Minhe Yang and Qi Chen*.Research Advances and Detection Methodologies for Microbe-Derived Acetylcholinesterase Inhibitors: A Systemic Review.Molecules 2017, 22(1). doi:10.3390/molecules22010176. 

[24] Qi Chen,Lijun Sun, Zhijian J Chen. Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing.Nature Immunology 2016,17(10): 1142-1149.

[25] Hanze Wang, Yansong Zheng, Junzhong Lai, Qianping Luo, Huican Ke, Qi Chen*.Methylation-Sensitive Melt Curve Analysis of the Reprimo Gene Methylation in Gastric Cancer.PLoS One DOI:10.1371/journal.pone.0168635 December 16, 2016.

[26] Qi Chen, Marguerite Prior, Richard Dargusch, Amanda Roberts, Roland Riek, Ce´ dric Eichmann, Chandramouli Chiruta, Tatsuhiro Akaishi, Kazuho Abe, Pamela Maher, David Schubert*. A Novel Neurotrophic Drug for Cognitive Enhancement and Alzheimer's Disease.PLoS One 2011,6(12):1-17.

[27] Federico Herrera, Qi Chen, and David Schubert.Synergistic effect of retinoic Acid and cytokines on the regulation of glial fibrillary acidic protein expression.Journal of Biological Chemistry 2010,285(50):38915-38922

[28] Xianjin Zhou, Qi Chen,Katie Schaukowitch, John R Kelsoe, and Mark A Geyer.Insoluble DISC1-Boymaw Fusion Proteins Generated by the DISC1 Translocation. Molecular Psychiatry 2010, 15(7): 670–672

[29] Qi Chen, Charles A. Peto, G. Diane Shelton, Andrew Mizisin,Paul E. Sawchenko,and David Schubert.Loss of MOCA reveals a pathway leading to axonal degeneration.Journal of Neurosciences 2009,29(1):118 –130

[30] Joseph R. Burdo, Qi Chen, Nigel A. Calcutt, David Schubert∗. The pathological interaction between diabetes and presymptomatic Alzheimer’s disease. Neurobiology of Aging 2009,1910–1917

[31] Federico Herrera, Qi Chen,Wolfgang H.Fischer, Pamela Maher, and David Schubert*.Synaptojanin-1 plays a key role in astrogliogenesis: possible relevance for Down’s syndrome.Cell Death and Differentiation 2009, 16(6): 910–920