林华研究员简介：

林华 博士

研究员，博士生导师，“闽江学者”特聘教授

福建省高层次引进人才境外B类

Email: hlin@fjnu.edu.cn

教育科研经历

1998.9-2002.6 复旦大学，化学系，本科

2002.7-2005.8 复旦勤益化学有限公司，研发人员

2005.9-2008.6 复旦大学化学系，硕士，导师：林国强院士

2008.9-2012.6 复旦大学化学系，博士，导师：林国强院士

2010.8-2011.8 GlaxoSmithkline, HIV DPU, RTP, USA，co-investigator

2012.7-2014.6 复旦大学生物医学研究院，博士后，合作导师：张晓燕教授

2014.7-2017.7 复旦大学药学院，博士后，合作导师：孙逊教授

2014.7-2019.5 The Scripps Research Institute, Jupiter, FL, USA, Research Associate, Dr. Theodore M. Kamenecka, Dr. Thomas D. Bannister

2019.6-2020.4 中国科学院上海药物研究所，特别研究助理

2020.5-至今，福建师范大学，南方生物医学研究中心，研究员

研究方向：

1）基于蛋白结构的药物分子设计与合成，靶向BPTF、CDK家族、RhoA、TEAD等新型抑制剂和降解剂的开发，为恶性肿瘤提供治疗与化学干预的药物先导化合物。

2）针对核激素受体ERRγ、PGC1α、PPARγ、GR等目标靶点设计合成具有体外和体内生物活性的小分子化合物, 为糖尿病、肥胖症等相关疾病提供治疗与化学干预的药物先导化合物。

3）药物化学方法学开发，为蛋白定点修饰提供化学基础。

基金资助：

国家自然科学基金面上项目，靶向CDK7/cyclin H复合物的选择性小分子降解剂的设计合成与活性研究，50万元，2024-2027，项目主持人

福建省自然科学基金面上项目,胺基化合物选择性碳氢官能团化研究及其应用, 10万元，2021-2024，项目主持人

已发表论文和专利

1. Yu Cao, Bin Wu, Ying Xu, Mingchen Wang, Xinyu Wu, Xiaochen Liang, Jin Lin, Zhihai Li, Hua Lin*, Cheng Luo*, Shijie Chen*, Discovery of GPX4 inhibitors through FP-based high-throughput screening, European Journal of Medicinal Chemistry, 2024, 116044. https://doi.org/10.1016/j.ejmech.2023.116044

2. Shasha Zhang,# Gong Zhang,# Jie Wang,# Yueyao Feng,# Zemin Zhang,# Si Xie, Ziying Lin, Shiling Yang, Jin Lin,* and Hua Lin*, Native Amino Group Directed Meta-Selective C−H Arylation of Primary Amines Via Pd/Norbornene Catalysis, Organic Letters, 2024, in press, https://doi.org/10.1021/acs.orglett.4c00721

3. Mingyu Wang^#, Rongkun Lin^#, Jiacheng Li^#, Yuying Suo^#, Jing Gao, Liping Liu, Liyuan Zhou, Yicheng Ni, Ziqun Yang, Jie Zheng, Jin Lin, Hu Zhou*, Cheng Luo*, Hua Lin*, Discovery of LL-K8-22: A Selective, Durable, and Small-Molecule Degrader of the CDK8-Cyclin C Complex, Journal of Medicinal Chemistry,2023, 66, 4932-4951 https://doi.org/10.1021/acs.jmedchem.2c02045.

4. Jing Gao,# Jie Yang, # Shengyu Xue, # Hong Ding, Hua Lin*, Cheng Luo*, Expert Opinion on Therapeutic Patents, 2023, 33, 265-292.

5. Rongkun Lin#, Jie Yang#, Ting Liu#, Mingyu Wang, Chongrong Ke, Cheng Luo, Jin Lin,* Jiacheng Li,* Hua Lin*, Chemistry & Biodiversity, 2023, 20, e202300769.

6. Weitong Yao,Yujun Li, Danting Ma, Xudong Hou, Haimin Wang, Xiaojuan Tang, Dechun Cheng, He Zhang, Chengzhi Du, Hong Pan, Chao Li, Hua Lin, Mengsi Sun, Qiang Ding, Yingjie Wang, Jiali Gao, Guocai Zhong*, Evolution of SARS-CoV-2 Spikes shapes their binding affinities to animal ACE2 orthologs animal ACE2 orthologs animal ACE2 orthologs, Microbiology Spectrum, 2023, 11, 6, e02676-23

7. Yueyao Feng,# Jie Wang,# Jie Yang,# Fengyuan Chen,# Zemin Zhang, Chongrong Ke, Jin Lin,* Hua Lin*, Native Amino Group Directed Site-Selective ε C(sp²)−H Iodination of Primary Amines, Organic Letters, 2023, 25, 9, 1348–1352, https://doi.org/10.1021/acs.orglett.2c04288.

8. Jiacheng Li^#, Ting Liu^#, Yuanli Song^#, Mingyu Wang, Liping Liu, Hongwen Zhu, Qi Li, Jin Lin, Hualiang Jiang, Kaixian Chen, Kehao Zhao, Mingliang Wang, Hu Zhou*, Hua Lin*, and Cheng Luo*, Discovery of Small-Molecule Degraders of the CDK9-Cyclin T1 Complex for Targeting Transcriptional Addiction in Prostate Cancer, Journal of Medicinal Chemistry,2022, 65, 11034-11057, https://doi.org/10.1021/acs.jmedchem.2c00257.

9. Haibo Lu,^‡ Shijia Zu,^‡ Zhe Duan,^‡ Yueyao Feng, Jie Wang, Jingyi Ma, Qi Li, Dongying Chen, Bo Li, Kaixian Chen, Cheng Luo, Jin Lin,* Tian Lu,* and Hua Lin*, Chinese Journal of Chemistry, 2022, 40, 2072-2080.

10. Haibo Lu,^‡ Tian Lu,^‡ Shijia Zu,^‡ Zhe Duan, Yiman Guang, Qi Li, Jingyi Ma, Dongying Chen, Bo Li, Wenchao Lu, Hualiang Jiang, Cheng Luo, Deyong Ye*, Kaixian Chen*, Hua Lin*, Discovery of a highly potent CECR2 bromodomain inhibitor with 7H-pyrrolo[2,3-d] pyrimidine scaffold, Bioorganic Chemistry, 2022, 123, 105768, https://doi.org/10.1016/j.bioorg.2022.105768.

11. Huimin Zhang, Jixiao He, Guang Hu, Fei Zhu, Hao Jiang, Jing Gao, Hu Zhou, Hua Lin, Yingjuan Wang, Kaixian Chen, Fanwang Meng, Minghong Hao, Kehao Zhao,* Cheng Luo,* and Zhongjie Liang*, Journal of Medicinal Chemistry, 2021, 64, 15111−15125

12. Tian Lu,^‡ Haibo Lu,^‡ Zhe Duan,^‡ Jun Wang, Jie Han, Senhao Xiao, HuanHuan Chen, Hao Jiang, Yu Chen, Feng Yang, Qi Li, Dongying Chen, Jin Lin, Bo Li, Hualiang Jiang, Kaixian Chen, Wenchao Lu*, Hua Lin*, and Cheng Luo*, Journal of Medicinal Chemistry, Discovery of High-Affinity Inhibitors of the BPTF Bromodomain, 2021, 64, 16, 12075–12088, https://doi.org/10.1021/acs.jmedchem.1c00721.

13. Hua Lin,^‡ Kfir Sharabi,^‡ Li Lin, Claudia Ruiz, Di Zhu, Michael D. Cameron, Scott J. Novick, Patrick R. Griffin, Pere Puigserver, and Theodore M. Kamenecka*, Journal of Medicinal Chemistry, Structure−Activity Relationship and Biological Investigation of SR18292 (16), a Suppressor of Glucagon-Induced Glucose Production, 2021, 64, 2, 980–990, https://dx.doi.org/10.1021/acs.jmedchem.0c01450.

14. Tian Lu, Yong Li, Wenchao Lu, T.W.G.M. Spitters, Xueyu Fang, Jun Wang, Simian Cai, Jing Gao, Yanting Zhou, Zhe Duan, Huan Xiong, Liping Liu, Qi Li, Hualiang Jiang, Kaixian Chen, Hu Zhou, Hua Lin, Huijin Feng, Bing Zhou*, Christopher L. Antos*, Cheng Luo*, Acta Pharmaceutica Sinica B, 2021, 11(10):3206-3219.

15. Yanli Sun,^‡ Haibo Lu,^‡ Xueyu Fang,^‡ Senhao Xiao, Feng Yang, Yantao Chen, Hongbo Wang, Xiaopeng Li, Jing Lu, Hua Lin, Cheng Luo, Kehao Zhao*, Shijie Chen*, Bioorganic & Medicinal Chemistry, 2021, 34, 116054.

16. Paola Munoz-Tello, Hua Lin, Pasha Khan, Ian Mitchelle S. de Vera, Theodore M. Kamenecka, and Douglas J. Kojetin*, Journal of Medicinal Chemistry,2020, 63, 15639−15654.

17. Yu Tan, Ru-Lin Ma, Hua Lin*, Xing-Wen Sun*, Tetrahedron Letters, 2020, 61, 152587.

18. Erica J. Young, Hua Lin, Theodore M. Kamenecka, Gavin Rumbaugh,* and Courtney A. Miller*, The Journal of Neuroscience, 2020, 40, 2695–2707.

19.Hua Lin,^‡ Xiaohong Pan,^‡ Adam L. Barsamian, Theodore M. Kamenecka, Thomas D. Bannister*, Native Directed Site-Selective δ C(sp3)−H and δ C(sp2)−H Arylation of Primary Amines, ACS Catalysis, 2019, 4887-4891. DOI: 10.1021/acscatal.8b04927.

20. Hua Lin, Chao Wang, Thomas D. Bannister, Theodore M. Kamenecka*, Chemistry–A European Journal, 2018, 24, 9535-9541.

21.Hua Lin,^‡ Jonathan Z. Long,^‡ Alexander M. Roche, Katrin J. Svensson, Florence Dou, Mi Ra Chang, Timothy Strutzenberg, Claudia Ruiz, Michael D. Cameron, Scott J. Novick, Charles M. Berdan, Sharon Louie, Daniel K. Nomura, Bruce M. Spiegelman, Patrick R. Griffin, Theodore M. Kamenecka*, Discovery of Hydrolysis-Resistant Isoindoline N Acyl Amino Acid Analogues that Stimulate Mitochondrial Respiration, Journal of Medicinal Chemistry, 2018, 61, 3224-3230. DOI: 10.1021/acs.jmedchem.8b00029.

22.Hua Lin, Christelle Doebelin, Rémi Patouret, Ruben D. Garcia-Ordonez, Mi Ra Chang, Venkatasubramanian Dharmarajan, Claudia Ruiz Bayona, Michael D. Cameron, Patrick R. Griffin, Theodore M. Kamenecka*, Bioorganic & Medicinal Chemistry Letters, 2018, 28, 1313-1319.

23. Jinsai Shang, Richard Brust, Sarah A. Mosure, Jared Bass, Paola Munoz-Tello, Hua Lin, Travis S. Hughes, Miru Tang, Qingfeng Ge, Theodore M. Kamenekca, Douglas J. Kojetin*,  eLife, 2018, 7:e43320.

24. Jonathan Z. Long, Alexander M. Roche, Charles A. Berdan, Sharon M. Louie, Amanda J. Roberts, Katrin J. Svensson, Florence Y. Dou, Leslie A. Bateman, Amir I. Mina, Zhaoming Deng, Mark P. Jedrychowski, Hua Lin, Theodore Kamenecka, John M. Asara, Patrick R. Griffin, Alexander S. Banks, Daniel K. Nomura, Bruce M. Spiegelman*, The Proceedings of the National Academy of Sciences, 2018, 2018, 115, E6937–E6945.

25. Richard Brust,^‡ Hua Lin,^‡ Jakob Fuhrmann, Alice Asteian, Theodore M. Kamenecka, and Douglas J. Kojetin*, ACS chemical biology, 2017, 12, 969-978.

26. Kfir Sharabi, Hua Lin, Clint D. J. Tavares, John E. Dominy, Roger Schilling, Amy K. Rines, Marc Hickey, Melissa Bennion, Partha P. Nag, José Perez, Mark P. Jedrychowski, Steve P. Gygi, Theodore M. Kamenecka, Stuart L. Schreiber, Patrick R. Griffin and Pere Puigserver*, Cell, 2017, 169, 148-160.

27. Yu Tan, Er-Lu Feng, Qiang-Sheng Sun, Hua Lin*, Xun Sun, Guo-Qiang Lin, and Xing-Wen Sun*, Organic & Biomolecular Chemistry, 2017, 15, 778 (cover article).

28. Zhuang Jin, Hua Lin, Sathish Srinivasan, Jerome C Nwachukwu, Nelson E Bruno, Patrick R Griffin, Kendall W Nettles*, Theodore Kameneck*, Bioorganic & Medicinal Chemistry Letters, 2017, 27, 347.

29. Jonathan Z. Long, Katrin J. Svensson, Leslie A. Bateman, Hua Lin, Theodore Kamenecka, Isha A. Lokurkar, Jesse Lou, Rajesh R. Rao, Mi Ra Chang, Mark P. Jedrychowski, Joao A. Paulo, Steven P. Gygi, Patrick R. Griffin, Daniel K. Nomura*, Bruce M. Spiegelman*, Cell, 2016, 166, 424–435.

30. Qiang-Sheng Sun, Hua Zhu, Hua Lin*, Yu Tan, Xiao-Di Yang, Xing-Wen Sun*, Xun Sun, Tetrahedron Letters, 2016, 57, 5768. 

31.  Qiang-Sheng Sun, Hua Lin*, Xun Sun, Xing-Wen Sun*, Tetrahedron Letters, 2016, 57, 5673.

32.  Sarbani Ghoshal, Qingzhang Zhu, Alice Asteian,Hua Lin, Haifei Xu, Glen Ernst, James C Barrow, Baoji Xu, Michael D Cameron, Theodore M Kamenecka, Anutosh Chakraborty*, Molecular Metabolism,2016, 5, 903–917.

33. Hua Lin, Yu Tan, Jian-Ming Wu, Xiao-Di Yang*, Jun-Hua Chen, Xing-Wen Sun*, Tetrahedron Letters,2015, 56, 913.

34. Qiang-Sheng Sun, Xiao-Yang Chen, Hua Zhu, Hua Lin, Xing-Wen Sun* and Guo-Qiang Lin, Organic Chemistry Frontiers, 2015, 2, 110.

35.Hua Lin, Xing-Wen Sun*, Guo-Qiang Lin, Organic Letters, 2014, 16, 752.

36. Yu Tan, Yong-Jian Chen, Hua Lin, Han-Lin Luan, Xing-Wen Sun,* Xiao-Di Yang and Guo-Qiang Lin*, Chemical Communications, 2014, 50, 15913.

37. Yu Tan, Han-Lin Luan, Hua Lin, Xing-Wen Sun*, Xiao-Di Yang, Han-Qing Dong and Guo-Qiang Lin*, Chemical Communications, 2014, 50, 10027.

38. Hua Lin, Yu Tan, Wen-Jie Liu, Zhi-Cheng Zhang, Xing-Wen Sun*, Guo-Qiang Lin*, Chemical Communications, 2013, 49, 4024.

39.Hua Lin, Yu Tan, Xing-Wen Sun*, Guo-Qiang Lin*, Organic Letters, 2012, 14, 3818.

40.Hua Lin, Yang Zang, Ru-Lin Ma, Xing-Wen Sun*, Guo-qiang Lin*, Chinese Journal of Chemistry, 2012, 30, 2309.

41.Hua Lin, Kyong-Sung Han, Xing-Wen Sun*, Guo-Qiang Lin*, Chinese Journal of Organic Chemistry, 2008, 28, 1479.

42.Hua Lin, Xing-Wen Sun*, Tetrahedron Letters, 2008, 49, 5343.

已申请和授权专利

1. Bruce M. Spiegelman, Jonathan Z. Long, Hua Lin, Theodore M. Kamenecka, Patrick R. Griffin, Chemical Uncouplers of Respiration and Methods of Use Thereof, Pub. No.: WO/2019/108739.

2. 林国强，孙兴文，林华，沈少春，臧扬，一种制备不对称双吲哚甲烷类化合物的方法，专利号：ZL 200910053428.1

3. 林国强，孙兴文，林华，沈少春，臧扬，李榕，钟毅，马伟伟，具有生物活性双吲哚甲烷类化合物，专利号：ZL 200910053430.9